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Ursodeoxycholic Acid

Cholesterol gallbladder stones that are not suitable for surgical treatment (the stones must be X-ray penetrable and the gallbladder contraction function must be normal). Prevent drug-induced stone formation. Cholestatic liver disease (such as primary biliary cirrhosis) and chronic liver disease with intrahepatic cholestasis. Bile reflux gastritis. Steatorrhea (after ileal resection).

The recommended oral daily dose for adults is 13 to 15 mg/kg, taken 2 to 4 times with food, and the dose should be adjusted according to the individual needs of the patient. When used for bile reflux gastritis, take 250 mg a day before going to bed at night. The minimum course of treatment is 6 months. If there is no improvement in the ultrasound examination and cholecystography after 6 months, the medication can be discontinued; if the stones have been partially dissolved, continue taking the medication until the stones are completely dissolved. Children take 8~10mg/kg orally daily, divided into 2~3 times.

Adverse reactions:
Adverse reactions observed in clinical trials include diarrhea, increased creatinine, increased blood sugar, leukopenia, peptic ulcer, rash, and thrombocytopenia. Adverse reactions observed in a randomized crossover study of 60 patients with primary biliary cirrhosis included abdominal pain, weakness, nausea, dyspepsia, anorexia, and esophagitis. Post-marketing reported adverse reactions are classified by organ system as follows: Digestive system: abdominal discomfort, abdominal pain, constipation, diarrhea, indigestion, nausea, vomiting. Systemic and administration site: general malaise, peripheral edema, fever. Immune system: Drug allergies, including facial edema, urticaria, angioedema, and laryngeal edema. Musculoskeletal and connective tissue: myalgia. Nervous system: dizziness, headache. Respiratory system: Cough. Skin and subcutaneous tissue: alopecia, pruritus, rash.

Drug contraindications:
Contraindicated if allergic to this product. Contraindicated if liver function is impaired. Use with caution during pregnancy. Use with caution during lactation. Use with caution in children.


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