Trilaciclib dihydrochloride injection 盐酸曲拉西利注射液

Trilaciclib hydrochloride is a cyclin-dependent kinase 4/6 (CDK4/6) inhibitor, mainly used to reduce chemotherapy-induced bone marrow suppression, and reduce the damage of chemotherapy to the immune system and blood system by protecting bone marrow hematopoietic stem cells and progenitor cells.

Indications and Mechanism of Action
Indications: It is suitable for patients with extensive-stage small cell lung cancer (ES-SCLC) before receiving chemotherapy containing platinum/etoposide or topotecan to reduce the risk of chemotherapy-induced bone marrow suppression.
Mechanism of Action: By inhibiting CDK4/6 activity, bone marrow stem cells are temporarily stagnant in the G1 phase of the cell cycle, reducing the killing of rapidly dividing cells by chemotherapy drugs, thereby protecting bone marrow function.
Usage and Dosage
Administration method: intravenous injection, infusion must be completed within 4 hours before the start of chemotherapy.
Recommended dose: usually 240 mg/m², which needs to be adjusted according to the patient’s body surface area and chemotherapy regimen, and must be strictly followed.
Precautions
‌Side effects‌:
Common symptoms include fatigue, hypocalcemia, headache, etc., and occasional injection site reactions or allergies.
Monitoring of blood routine (such as neutrophil and platelet counts) and electrolyte levels is required.
‌Contraindications‌:
Those who are allergic to the drug ingredients are prohibited from using this drug; pregnant and lactating women and those with severe liver and kidney dysfunction need to carefully assess the risks.
‌Drug interactions‌:
When used in combination with other bone marrow suppressive drugs, side effects may be aggravated. The doctor should be informed of the drugs being used.
Clinical significance
Studies have shown that triclasiclib hydrochloride can significantly reduce the need for chemotherapy dose adjustments or delays due to bone marrow suppression and improve treatment tolerance, but it cannot replace the anti-tumor effect of chemotherapy itself. A comprehensive plan should be formulated based on the specific condition.

‌Note‌: Triraciclib hydrochloride is a prescription drug. It must be evaluated by a professional doctor before use and follow the medication instructions throughout the process. Do not adjust the dose or stop the drug on your own.