Succinate Mobocertinib capsule，ExkivityTAK-788 琥珀酸莫博赛替尼胶囊

Mobocetinib succinate capsules are an oral targeted therapy for non-small cell lung cancer (NSCLC) with specific gene mutations. They are mainly used for locally advanced or metastatic patients with EGFR exon 20 insertion mutations. The drug blocks tumor growth signals by inhibiting abnormally activated EGFR proteins and must be used strictly in accordance with doctor’s instructions.

Core information
Indications

It is suitable for adult patients with NSCLC with EGFR exon 20 insertion mutations who have progressed during or after previous platinum-containing chemotherapy.
The mutation status must be confirmed by genetic testing and should not be used blindly.
Mechanism of action

As a tyrosine kinase inhibitor (TKI) for EGFR exon 20 insertion mutations, it selectively inhibits the activity of mutant proteins and reduces cancer cell proliferation.
Usage and dosage

Usually taken orally once a day, on an empty stomach or with meals, the specific dosage is adjusted by the doctor according to the patient’s condition.
Do not stop the drug or increase or decrease the dosage on your own to avoid affecting the efficacy or aggravating side effects.
‌Common side effects‌

Gastrointestinal or skin reactions such as diarrhea, rash, stomatitis, and nausea are common, and most of them can be relieved by symptomatic treatment.
Be alert to serious adverse reactions such as cardiotoxicity (such as QT interval prolongation) and interstitial lung disease. See a doctor immediately if you have difficulty breathing or chest pain.
‌Precautions‌

Monitor electrocardiogram, electrolytes and liver function regularly during medication to evaluate drug safety.
Avoid combined use with strong CYP3A inhibitors/inducers, which may affect blood drug concentrations.
Pregnant women, lactating women and those with impaired liver and kidney function should be cautious and fully assess the risks before treatment.
‌Medical guidance‌

This drug is a prescription drug and must be prescribed by an oncologist based on the patient’s genetic test results and overall condition.
Keep in touch with the doctor during treatment, provide timely feedback on medication reactions, and regularly review and evaluate the efficacy.
‌Tips‌: Targeted therapy requires individualized plans. Patients should cooperate with doctors to complete standardized treatment and avoid listening to non-professional advice.