Rituximab Injection利妥昔单抗注射液

Effects and efficacy:
It is suitable for the treatment of relapsed or conventionally ineffective follicular central lymphoma (belonging to the three subtypes of B, C, and D in B-cell non-Hodgkin’s lymphoma, which is characterized by abnormal proliferation of lymph nodes). It is used for the first diagnosis of CD20-positive stage III-IV follicular non-Hodgkin’s lymphoma (cancer has developed to the middle and late stages), and needs to be used in combination with CVP chemotherapy for 8 treatment cycles. CVP chemotherapy contains three drugs: cyclophosphamide (destroys cancer cell DNA), vincristine (prevents cell division), and prednisone (anti-inflammatory hormone). It is used to treat CD20-positive diffuse large B-cell non-Hodgkin’s lymphoma (a type of lymphoma that grows quickly), and needs to be combined with CHOP chemotherapy for 8 cycles of treatment. CHOP chemotherapy contains four drugs: cyclophosphamide, doxorubicin (interferes with cancer cell replication), vincristine, and prednisone.
Dosage and Administration: Follicular non-Hodgkin’s lymphoma: Antipyretic analgesics (such as paracetamol) and antihistamines (such as diphenhydramine) should be used before each infusion of this product. Glucocorticoids should also be used in advance, especially if the treatment regimen used does not include corticosteroids. Initial treatment: As a single treatment for adult patients, the recommended dose of this product is 375mg/m2 BSA (body surface area), intravenous administration, once a week, for a total of 4 doses within a 22-day course of treatment. When combined with CVP chemotherapy, the recommended dose of this product is 375mg/m2 BSA for 8 consecutive cycles (21 days/cycle). Take corticosteroids orally first each time, and then give it on the first day of the chemotherapy cycle. Re-treatment after relapse: For patients who relapse after the first treatment, the retreatment dose is 375mg/m2 BSA, intravenous infusion for 4 weeks, once a week. Diffuse large B-cell non-Hodgkin’s lymphoma: Antipyretics (such as paracetamol) and antihistamines (such as diphenhydramine) should be used before each infusion of this product. Glucocorticoids should also be used in advance, especially if the treatment regimen used does not include corticosteroids. This product should be used in combination with CHOP chemotherapy. The recommended dose is 375mg/m2 BSA, used on the first day of each chemotherapy cycle. Other components of chemotherapy should be used after the application of this product.
Adverse reactions:
Common adverse reactions are numbness and tingling in the hands and feet, easy fatigue, night sweating, weight gain, dizziness and headache, difficulty sleeping, red and itchy skin, swollen hands and feet, palpitations, chest tightness, diarrhea, stomach pain, etc. More than 1 in 10 people will experience these reactions. About 1 to 10 people in 100 may experience low blood pressure, chest tightness, cold hands and feet, tingling in the hands and feet, burning in the stomach, muscle cramps, joint pain, labored breathing, tight throat, etc. Very few people (less than 1 in every 100 people) may experience severe allergic reactions, acute kidney damage, liver failure, lung infection, sudden heart attack, large-area blistering and ulceration of the skin, and other dangerous conditions. Serious conditions that require special attention include: possible fatal brain infection diseases. If you have difficulty speaking, confusion, blurred vision, limb weakness and other symptoms, you should contact a doctor immediately; intestinal blockage or rupture is prone to occur in the early stage of medication. If you have severe abdominal pain accompanied by vomiting, you should seek medical attention immediately; hepatitis B virus may become reactivated and cause liver damage, and liver function should be checked regularly before and after medication; allergic reactions such as skin redness, difficulty breathing, and violent heartbeat may occur during infusion, and you need to stop taking the medicine immediately; severe skin reactions such as blistering all over the body and large pieces of epidermis falling off, if such situations occur, you need to stop taking the medicine immediately.
Drug contraindications:
Allergic to this product is prohibited. It is prohibited during pregnancy and lactation.
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