ritodrine

Effects and efficacy:
It can be used to prevent premature birth after 20 weeks of pregnancy.
Usage and dosage:
Two intravenous injections, a total of 100 mg, are diluted with 500 ml of 5% glucose injection (500 ml of sodium chloride injection can be used for diabetic patients) to a solution of 0.2 mg/ml, and are used within 48 hours. During intravenous infusion, the patient should remain in the left lateral position to reduce the risk of hypotension. When the infusion begins, the drip rate should be controlled to 0.05 mg/min (5 drops/min, 20 drops/ml), and increased by 0.05 mg/min (increase by 5 drops/min) every 10 minutes until the desired effect is achieved. It is usually maintained between 0.15 and 0.35 mg/min (15 to 35 drops/min), and the drip is continued for 12 to 18 hours after the uterine contraction stops. During the intravenous infusion, the pregnant woman’s pulse is maintained at <140 beats/min. Blood sugar and blood potassium should be monitored during medication. Note: If the injection solution changes color or precipitates (or crystals) appear, it cannot be used again. Oral medication: Oral treatment begins 30 minutes before the end of intravenous infusion. For the first 24 hours, take 10 mg (1 tablet) every 2 hours, and then 10-20 mg (1-2) tablets every 4-6 hours. The total daily dose should not exceed 120 mg (12 tablets). The usual daily maintenance dose is between 80-120 mg (8-12 tablets). For the purpose of preventing premature birth, maintenance treatment can continue to be taken orally at this dose. Adverse reactions: This product is not selective for the β`-2` receptor. Pregnant women may experience increased maternal and fetal heart rates (average 130 beats/min and 164 beats/min, respectively), and increased maternal blood pressure. Serious adverse reactions: rhabdomyolysis (muscle pain, weakness, increased CPK, increased myoglobin in blood and urine); neonatal intestinal occlusion; low serum potassium caused by β`-2` receptor agonists. Other adverse reactions: Cardiovascular system: palpitations, tachycardia, and rare facial flushing. Fetal tachycardia and arrhythmia. Liver: Sometimes, elevated levels of aspartate aminotransferase (AST) and alanine aminotransferase (ALT) can be seen. Blood system: Rarely, thrombocytopenia. Mental and nervous system: Sometimes, there is tremor, and rarely, there is gait instability. Digestive system: Sometimes, there is abdominal pain and vomiting. Allergies: Rarely, there is a rash. Drug contraindications: Allergic to this product is prohibited. It is prohibited in early pregnancy and during lactation.