Recombinant Human Tumor Necrosis Factor-α ReceptorⅡ:IgG Fc Fusion Protein. 益赛普（注射用重组人Ⅱ型肿瘤坏死因子受体抗体融合蛋白）

Effects and efficacy:
Moderate and severe active rheumatoid arthritis, active ankylosing spondylitis, moderate and severe plaque psoriasis in adults and other diseases. Rheumatoid arthritis: This product can be used in combination with methotrexate for treatment of adult patients with moderate to severe active rheumatoid arthritis who are ineffective with DMARDs (disease-modifying antirheumatic drugs) including methotrexate (if not contraindicated). Ankylosing spondylitis: This product can be used for treatment of adult patients with active ankylosing spondylitis who are ineffective with conventional treatment. Psoriasis: This product can be used for moderate and severe plaque psoriasis in adults aged 18 years and over who are ineffective with conventional treatment.

Dosage and administration:
Dosage Adults (18-64 years old) with rheumatoid arthritis, ankylosing spondylitis, and psoriasis: The recommended dose is 25 mg/time, twice a week (72-96 hours apart). Children: There is no data on the use of the drug for children under 2 years old. According to foreign reports, the dosage for children is 0.8 mg/kg per week. The recommended weekly dosage is given twice, with an interval of 3-4 days between each dose. Elderly patients (≥65 years old): No dosage adjustment is required. The dosage and administration are the same as those for adults aged 18-64 years. Since infections are usually more likely to occur in elderly patients, attention should be paid during treatment. Patients with impaired liver and kidney function do not need to adjust the dosage. Injection site and route The injection site of this product is the thigh, abdomen and upper arm, and the injection method is subcutaneous injection. Each injection is made in a different site, at least 3 cm away from the previous injection site. It is forbidden to inject into tender, bruised, red or hard parts of the skin. Disposal The lyophilized powder of this product must be stored in a refrigerator at 2℃-8℃ before use and cannot be frozen. The lyophilized powder of this product needs to be reconstituted with 1ml of water for injection before use. This product should be used immediately after dissolution. The dissolved injection solution should be stored in a refrigerator at 2℃-8℃ and can be stored for up to 24 hours. If it is not used within 24 hours, it should be discarded. Refrigerated solution should be rewarmed to room temperature before injection.

Drug contraindications:
Forbidden for children; Forbidden for those allergic to this product; Use with caution during pregnancy; Use with caution during lactation; Use with caution during pregnancy preparation
Related dosage forms:
Injection