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Polystyrene sulfonates are a group of drugs used to treat hyperkalemia. [1] The effects usually take from hours to days. [1] They are also used to remove potassium, calcium, and sodium from solutions in technological applications.

Common side effects include loss of appetite, gastrointestinal discomfort, constipation, and hypocalcemia. [1] These polymers are derived from polystyrene with the addition of sulfonate functional groups.

Sodium polystyrene sulfonate was approved for medical use in the United States in 1958. [1]

Polystyrene sulfonates were developed in the 2000s for the treatment of Clostridium difficile-associated diarrhea under the name Tolevamer

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