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Oxaliplatin injection

Effects and efficacy: This product is mainly used for the first and second-line treatment of advanced colorectal cancer and postoperative adjuvant chemotherapy for early patients; it is effective for ovarian cancer, breast cancer, gastric cancer, pancreatic cancer, non-small cell lung cancer, melanoma, testicular tumors and lymphoma.
Usage and dosage: Single drug application: The recommended dose is 130mg/m, added to 250-500ml 5% glucose solution, intravenous drip for 2-6 hours, repeated once every 3 weeks. The dose of this product should not exceed 200mg/m to avoid neurotoxicity. There is no need to adjust the dose for patients with mild or moderate renal insufficiency or mild hepatic insufficiency, but it should be used with caution for patients with severe hepatic and renal insufficiency. Combined with fluorouracil: The dose of the next administration should be adjusted according to the degree of bone marrow suppression. If 4-degree diarrhea, 3-4-degree granulocytopenia and (or) 3-4-degree thrombocytopenia occur, the dose of this product should be reduced by 25%, and the dose of fluorouracil should also be reduced. Combined chemotherapy: mainly combined with calcium folinate (CF), fluorouracil, and in recent years also with gemcitabine. The dosage of this product is the same as above. The same infusion bottle cannot be used for fluorouracil infusion, and it is best to be 1 hour apart. The adjustment of dosage should be based on safety, especially neurological safety. Instructions for use Oxaliplatin must be prepared and further diluted before use. The freeze-dried powder preparation must be dissolved and diluted with the specified solution. Instructions for use As with other cytotoxic drugs, the use and preparation of oxaliplatin must be carried out carefully and cautiously in accordance with the precautions. Instructions for operation When handling this cytotoxic drug, medical staff and nurses should be cautious in every step to ensure the safety of themselves and the surrounding environment. The preparation of cytotoxic drug injection solutions must be carried out by professionals who have been professionally trained and have medical knowledge to ensure the safety of the environment, especially the safety of the preparer himself. To achieve this goal, a dedicated area is required. Smoking, eating and drinking are prohibited in this area. The preparer must be well equipped. Long-sleeved work clothes, protective masks, hats, protective glasses, disposable sterile gloves, protective covers on the workbench, and special containers for waste. The patient’s excrement and vomitus must be properly handled. Pregnant women should avoid contact with cytotoxic drugs. Any broken containers must be handled with the same care as contaminated materials. Contaminated waste should be incinerated in labeled hard containers. If oxaliplatin powder, reconstituted material or solution contacts the skin or mucous membrane, it should be immediately rinsed with plenty of water. Special precautions for use Do not use injection materials containing aluminum. Do not use without dilution. Do not prepare or dilute this product with saline solution. Do not mix with any other drugs or use them simultaneously through the same infusion channel (especially 5-fluorouracil, alkaline solution, tromethamine and folinic acid drugs containing excipient tromethamine). After infusing oxaliplatin, the infusion tube needs to be flushed. Only recommended solvents can be used. If there is any precipitate in the prepared solution, it cannot be used again and should be destroyed in accordance with the handling principles of hazardous materials required by regulations. Preparation of solution When preparing the solution, water for injection or 5% glucose solution should be used. 10 ml of solvent should be added to the 50 mg package to make the oxaliplatin concentration reach 5.0 mg/ml. From the perspective of microbiology and chemistry, the prepared solution must be diluted immediately with 5% glucose solution. Before use, its transparency should be checked, and only clear solutions without precipitation can be used. This product is for single use, and any remaining solution should be discarded. Dilution before injection Take out the prepared solution from the bottle and immediately dilute it with 250~500 ml of 5% glucose solution to a solution with a concentration of more than 0.2 mg/ml, and then infuse it intravenously. Under normal circumstances, the physicochemical stability of the solution can be maintained for 24 hours between 2℃ and 8℃. From a microbiological point of view, this solution should be used immediately. If it is not used immediately, the user must ensure the storage time and conditions before use. Under normal circumstances, it should not exceed 24 hours between 2℃ and 8℃, unless the dilution is carried out under controlled and confirmed sterile conditions. Before use, its transparency should be checked, and only clear solutions without precipitation can be used. This product is for single use only and any remaining solution should be discarded. Do not prepare or dilute this product with saline solution. Oxaliplatin does not require prehydration for infusion. Oxaliplatin is diluted with 250-500 ml of 5% glucose solution to a concentration of 0.2 mg/ml or above and must be infused through a peripheral or central vein for 2-6 hours. When oxaliplatin and 5-fluorouracil are used together, oxaliplatin should be used before 5-fluorouracil. Waste disposal Any remaining drugs, as well as all items used for preparation, dilution and injection, must be destroyed in accordance with standard hospital procedures for cytotoxic drugs and current legal provisions for the disposal of toxic waste. The same drugs produced by different manufacturers may have inconsistent instructions. If you find inconsistencies in the instructions before taking the drug, please consult your doctor or pharmacist in time.
Drug contraindications:
Allergy to this product is prohibited. Renal impairment is prohibited. Lactation is prohibited. Use with caution in liver and kidney dysfunction. Use with caution during pregnancy
Related dosage forms: