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Moxifloxacin hydrochloride

Effects and efficacy:
For acute bacterial sinusitis: caused by Streptococcus pneumoniae, Haemophilus influenzae or Moraxella catarrhalis. For acute bacterial exacerbation of chronic bronchitis: caused by Streptococcus pneumoniae, Haemophilus influenzae, Haemophilus parainfluenzae, Klebsiella pneumoniae, Staphylococcus aureus or Moraxella catarrhalis. For community-acquired pneumonia: caused by Streptococcus pneumoniae, Haemophilus influenzae, Moraxella catarrhalis, Staphylococcus aureus, Klebsiella pneumoniae, Mycoplasma pneumoniae or Chlamydia pneumoniae. For simple skin and its appendages infection: caused by Staphylococcus aureus or Streptococcus pyogenes. For complicated intra-abdominal infection: caused by Escherichia coli, Bacteroides fragilis, Streptococcus anginosus, Streptococcus constellatus, Enterococcus faecalis, Proteus mirabilis, Clostridium perfringens, Bacteroides thetaiotaomicron or Peptostreptococcus. For complicated skin and skin structure infections: caused by Staphylococcus aureus (methicillin-sensitive strains), Escherichia coli, Klebsiella pneumoniae, and Enterobacter cloacae. In addition, this product can also be used as part of a multidrug treatment regimen for leprosy; eye drops can be used to treat eye infections caused by sensitive bacteria.

Dosage and administration:
The oral and intravenous doses are the same, both once a day, 400 mg each time. The specific course of treatment for the following infections is as follows: acute bacterial sinusitis, 10 days; acute bacterial infection of chronic bronchitis, 5 days; community-acquired pneumonia, 7-14 days; simple skin and its accessory structure infections, 7 days. Please follow the doctor’s advice for details. Combined with appropriate antibacterial therapy for eradication of Helicobacter pylori: 0.4g once a day, orally after meals, 7 or 10 days; for areas with severe drug resistance, it can be considered to be appropriately extended to 14 days, but not more than 14 days. Please follow the doctor’s advice for details. Eye drops: 1 drop at a time, 2-3 times a day, 7 days of treatment. Please consult a doctor for details.

Adverse reactions:
Adverse reactions with an incidence rate of ≥ 3%: nausea (7%), diarrhea (6%), dizziness (3%), dry eyes (1%-6%), decreased visual acuity (1%-6%). Adverse reactions with an incidence of 0.1%-3% include: systemic reactions, such as headache, abdominal pain, pain at the injection site, lower limb pain, back pain, chest pain, severe allergic reactions; vomiting, lack of appetite, dry mouth, constipation, abdominal distension, diarrhea, abnormal liver function, cholestatic jaundice, etc.; palpitations, tachycardia, hypertension, limb edema, QT interval prolongation, etc.; insomnia, nervousness, anxiety, drowsiness, confusion, paresthesia, tremor and dizziness; joint pain, myalgia; rash, itchy skin, sweating; vulvovaginal candidiasis, vaginitis; dyspnea, abnormal taste; increased amylase, increased lactate dehydrogenase, decreased prothrombin, increased eosinophils, decreased white blood cell count, decreased or increased platelet count. Rare adverse reactions (incidence <0.1%) include arthritis, visual abnormalities, hallucinations, epileptic seizures, abnormal electrocardiograms, atrial fibrillation, torsade de pointes, hypotension; hyperglycemia, jaundice, hepatitis, liver necrosis, liver failure, allergic alveolitis, acute renal failure; Stevens-Johnson syndrome, toxic exfoliative necrosis, tendinitis, tendon rupture; agranulocytosis, aplastic anemia, hemolytic anemia, various types of hematopoiesis, serum sickness, etc. In addition, the global adverse event reports after the launch of this product also include anaphylactic shock, heart failure and pseudomembranous colitis. Drug contraindications: Children are prohibited from using this product. It is prohibited during lactation. It is prohibited during pregnancy. It is prohibited for those who are allergic to this product.