Methylene blue injection is indicated for methemoglobinemia caused by chemicals such as nitrite, nitrate, aniline, nitrobenzene, trinitrotoluene, benzoquinone, phenylhydrazine, etc. and drugs containing or producing aromatic amines (acetanilide, acetaminophen, phenacetin, benzocaine, etc.). It is less effective for methemoglobinemia caused by congenital reduced diphosphate pyridine nucleoside methemoglobin reductase deficiency. It is ineffective for abnormal hemoglobin M with methemoglobinemia. It can temporarily delay the toxicity of acute cyanide poisoning.
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