Methotrexate Injection

Methotrexate injection, indications: Methotrexate has a broad spectrum of anti-tumor activity and can be used alone or in combination with other chemotherapy drugs. The specific indications are as follows: 1. Anti-tumor treatment, used alone: ​​breast cancer, gestational choriocarcinoma, malignant hydatidiform mole or hydatidiform mole. 2. Anti-tumor treatment, used in combination: acute leukemia (especially acute lymphocytic leukemia), Burkitts lymphoma, advanced lymphosarcoma (stage III and IV, according to Peter staging) and advanced mycosis fungoides. 3. Intrathecal injection: treatment of meningeal metastasis (only isotonic preparations can be used). 4. High-dose treatment: high-dose methotrexate is used alone or in combination with other chemotherapy drugs to treat the following tumors: osteosarcoma, acute leukemia, bronchial lung cancer or head and neck epidermal cancer. When high-dose methotrexate is used, folinic acid must be used for rescue. Folinic acid is a derivative of tetrahydrofolate and can compete with methotrexate to enter cells. This “folinic acid rescue” can protect normal tissue cells from damage when high-dose methotrexate is used. 5. Chemotherapy for psoriasis: Methotrexate can be used to treat severe, stubborn, and disabling psoriasis that is insensitive to conventional treatments. However, due to the high risk of use, it should be used after a clear diagnosis through biopsy and/or consultation with a dermatologist.