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Metahydroxylamine can be used to prevent and treat acute hypotension that occurs during neuraxial anesthesia. It can also be used for the auxiliary symptomatic treatment of some hypotension, including hypotension caused by bleeding, drug allergy, surgical complications, brain trauma or brain tumor combined with shock. It can also be used for hypotension caused by cardiogenic shock or sepsis.

Metahydroxylamine can be administered by intramuscular or subcutaneous injection, or by intravenous injection or infusion. The specific dosage varies depending on age, etc. This product has an accumulation effect. If the blood pressure does not rise significantly after taking the medicine, you must observe it for more than 10 minutes before deciding whether to increase the dose to avoid rash increases that may cause the blood pressure to rise too high. Adult dosage: Intramuscular or subcutaneous injection, 2 to 10 mg (1/5 vial – 1 vial, calculated as metahydroxylamine) once. Since the maximum effect is not immediately apparent, the effect of the initial dose should be observed for at least 10 minutes before repeated administration; For intravenous injection, the initial dose is 0.5~5 mg (1/20~1/2 tube), followed by intravenous infusion for severe shock; for intravenous infusion, add 15~100 mg metahydroxylamine (1.5~10 tubes). Instill 500 ml of 5% glucose solution or sodium chloride injection, and adjust the drip rate to maintain appropriate blood pressure. The maximum dosage for adults is 100mg (10 bottles) once, 0.3~0.4 mg per minute. Pediatric dosage: intramuscular or subcutaneous injection, 0.1 mg/kg, for severe shock; intravenous infusion, 0.4 mg/kg or 12 mg/m2 body surface area, diluted with sodium chloride injection to contain per 25 ml A 1 mg solution of metahydroxylamine, dripping at a rate that maintains an appropriate blood pressure level. It should be used within 24 hours after preparation. Other drugs that are difficult to dissolve in acidic solutions and are incompatible with the infusion should not be added to the infusion solution.

Drug contraindications:
Disabled if allergic to this product
Related dosage forms:
Metahydroxylamine Bitartrate Injection