Macitentan Tablets

Macitentan tablets are an endothelin receptor antagonist (ERA) clinically used to treat pulmonary arterial hypertension (PAH, WHO Group 1) to delay disease progression.
Pulmonary arterial hypertension: This product is used as a single agent or in combination with phosphodiesterase-5 inhibitors and inhaled prostaglandins to treat idiopathic or hereditary pulmonary arterial hypertension, pulmonary arterial hypertension associated with connective tissue disease, and pulmonary arterial hypertension associated with repaired congenital heart disease.
Disease progression includes: death, intravenous (IV) or subcutaneous administration of prostaglandins, or clinical worsening of PAH (decreased 6-minute walk distance, worsening PAH symptoms and need for additional PAH treatment). This product also reduces hospitalization in patients with PAH.