Chlormethine Hydrochloride Injection

Functions and indications:
Nitrogen mustard hydrochloride tincture: used for vitiligo. Nitrogen mustard hydrochloride liniment: used for external treatment of mycosis fungoides. Nitrogen mustard hydrochloride injection: used for the treatment of malignant lymphoma, especially Hodgkin’s disease. Intracavity administration has a good effect on controlling cancerous pleural, pericardial and abdominal effusions.
Usage and dosage:
The dosage and usage of this product may vary in different dosage forms and specifications. Please read the specific drug instructions for use, or follow the doctor’s advice. Nitrogen mustard hydrochloride tincture: for external use, twice a day, use a cotton swab or brush to dip the liquid and gently apply it to the affected area. Nitrogen mustard hydrochloride liniment: take 1ml of this product and dilute it with ethanol to 200ml (containing 0.05% nitrogen mustard hydrochloride), and apply it to the affected area. Nitrogen mustard hydrochloride injection: 1. Intravenous injection: 4-6mg/m2 (or 0.1mg/kg) each time, add 10ml of normal saline and flush it from a small infusion pot or leather tube, and flush the blood vessels with normal saline or 5% glucose solution, once a week, use it twice in a row, rest for 1-2 weeks and repeat. 2. Intracavitary administration: 5-10mg each time, dilute with 20-40ml of normal saline, inject immediately after drawing liquid, once a week, and repeat as needed. 3. Local skin application: newly prepared 5mg each time, add 50ml of normal saline, 1-2 times a day, mainly used for skin mycosis fungoides.
Adverse reactions:
Nitrogen mustard hydrochloride tincture: During the medication process, if the patient has allergic symptoms such as swelling and itching, 3-5 bottles of promethazine hydrochloride injection (2ml:50mg) can be added to this solution for desensitization treatment. If desensitization can be achieved, it can continue to be used, otherwise it should be stopped. Nitrogen mustard hydrochloride liniment: concentrated solution can irritate and corrode the skin, and needs to be diluted for external use. Nitrogen mustard hydrochloride injection: 1. Bone marrow suppression: mainly manifested as leukopenia and thrombocytopenia, which can lead to pancytopenia in severe cases. The lowest value of leukopenia is on the 7th to 10th day after injection of this product, and it can be restored after 1-2 weeks of discontinuation. 2. Gastrointestinal reactions: nausea and vomiting often occur 3-6 hours after injection and can last for 24 hours. 3. Reproductive function effects: including testicular atrophy, sperm reduction, reduced sperm motility and infertility, and menstrual disorders and amenorrhea in women. Other reactions include hair loss, fatigue, dizziness, and ulcers when injected outside the blood vessels. 4. Local application can produce delayed skin allergic reactions. 5. Conventional doses of nitrogen mustard have no significant effect on liver and kidney function.
Contraindications:
Nitrogen mustard hydrochloride tincture: 1. It is contraindicated for those who are allergic to this product. 2. It is contraindicated for pregnant women and lactating women. 3. It is contraindicated for children. Nitrogen mustard hydrochloride ointment: It is contraindicated for those who are allergic to this product. Nitrogen mustard hydrochloride injection: Anyone with bone marrow suppression, infection, tumor cell invasion and