Amphotericin B Cholesteryl Sulfate Complex for Injection.

Amphotericin B cholesterol sulfate complex is an anti-infective drug. It is a polyene anti-infective drug suitable for visceral or systemic infections caused by sensitive bacteria. Its main function is to damage the permeability of the cell membrane by combining with the sterols on the cell membrane of sensitive fungi, causing some important substances in the cell, such as nucleotides and potassium ions, to leak out, thereby destroying the normal metabolism of the cell and inhibiting the growth of fungi.

Amphotericin B cholesterol sulfate complex is mainly used clinically for Cryptococcus neoformans, Cyclosporon, Candida, Histoplasma and some Aspergillus species. It is often used as the first choice in the treatment of Penicillium marneffei and cryptococcal meningitis.

The drug concentration achieved by the commonly used therapeutic dose of amphotericin B cholesterol sulfate complex only has an antibacterial effect on fungi. The course of treatment should be determined according to the condition and type of disease. A full course of treatment is recommended. The use of this drug may be accompanied by fever, headache, loss of appetite, nausea, vomiting and other reactions. During use, the patient’s condition should be closely observed and must be used under the guidance of a doctor.